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Polynucleotides are advanced injectable biostimulators derived from purified DNA fragments that work deep within the skin to stimulate cell renewal and collagen production. This regenerative treatment enhances hydration, firmness, and elasticity, helping to restore a youthful, radiant complexion. Ideal for tired, ageing, or damaged skin, Polynucleotides improve skin texture, reduce fine lines, and support long-term skin health—all without adding volume. The results build progressively, leaving skin revitalised and naturally refreshed.
Polynucleotides are injectable biostimulators derived from purified DNA fragments that promote tissue repair, cell renewal, and deep skin regeneration. Unlike dermal fillers, they don't add volume—instead, they work with your body to improve skin quality from within.
This advanced treatment enhances hydration, elasticity, and firmness, making it ideal for restoring radiance to tired, ageing, or damaged skin.
Discover the transformative benefits and results you can expect from this treatment
Stimulates tissue repair and cellular renewal for healthier skin.
Improves skin moisture levels, leaving it plump and radiant.
Restores firmness and resilience for a more youthful look.
Reduces roughness, scars, and uneven tone for clearer skin.
Calms redness, irritation, and oxidative stress.
Biocompatible treatment with minimal downtime or risk.
NEWEST is an advanced bio-revitalising injectable developed by Mastelli Aesthetic in Italy. It combines three active ingredients—polynucleotides (PN-HPT), hyaluronic acid, and mannitol—to deliver deep skin regeneration and hydration.
Treatment Benefits
NEWEST is suitable for addressing signs of ageing, dehydration, dullness, loss of firmness, and skin texture concerns. It can be used on the face, neck, décolleté, and hands, restoring radiance and improving skin quality.
Clinical studies show noticeable improvements in elasticity, brightness, hydration, and smoothness, with reduced wrinkles and fine lines after treatment.
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| Feature | Polynucleotides | Skin Boosters |
|---|---|---|
| Main Action | Cell regeneration and DNA repair | Hydration and skin texture improvement |
| Primary Benefit | Stimulates collagen, repairs damaged tissue | Increases skin moisture and glow |
| Ideal For | Ageing, scarred, inflamed, or crepey skin | Dull, dehydrated or fine-lined skin |
| Combination Potential | Excellent with microneedling or skin boosters | Often combined with mesotherapy or PRP |
Polynucleotides work beautifully alongside other regenerative or collagen-boosting treatments. For enhanced results, they can be combined with:
Your practitioner will help design a bespoke combination plan tailored to your skin goals.
Polynucleotide injections are ideal if you want to:
A typical course includes 3 to 4 sessions, spaced 2 to 4 weeks apart, depending on the area treated and the condition of the skin. Maintenance sessions every 6 months help prolong and enhance results over time.
